Sema4 Signal® Hereditary Cancer

Sema4 understands the importance of proactive screening to help catch cancer early. We offer hereditary cancer screening solutions to help identify a person’s potential for developing breast cancer, including a brief online Hereditary Cancer Family History Questionnaire to help ensure patients in need of further surveillance are not missed.

What is hereditary cancer?


Cancer is a common disease.1 In some cases, the cancer is caused by a change, or variant, in a gene that is passed on in the family. This is often referred to as hereditary cancer. Patients with these gene variants have an increased chance to develop cancer, often at younger ages. Knowing if you have an increased chance to develop cancer may enable you and your healthcare provider to take steps to reduce this risk.

Facts about hereditary cancer:

  • Studies have shown that 1 in 8 cancer diagnoses may be associated with a hereditary cause2
  • 1 in 5 patients have a personal or family history suggestive of hereditary cancer3-5
  • Most individuals with hereditary cancer have a 50% chance to pass the genetic variant to their children6

What is hereditary cancer testing and why is it important?


Genetic testing for hereditary cancer is a way to examine your DNA for certain gene variants that have been shown to increase the likelihood of developing cancer. Knowing your hereditary cancer risk can help you take steps to better prevent, detect, or treat certain cancers.

View Patient Info Card


Jennifer Reynolds, founder of Pink Warrior Advocates, discusses her experience with a late-stage breast cancer diagnosis, the importance of proactive screening, and the impact it has had on her life.

Assessing your own personal risk for hereditary cancer

Have you assessed your risk for the potential of hereditary cancer? As a first step, take our brief online Hereditary Cancer Family History Questionnaire to help determine your risk level. You can share your results with your healthcare provider to learn if you may benefit from hereditary cancer testing.

Start Questionnaire

Still have questions?


Click here for more information or download a copy of our Hereditary Cancer Patient Info Card.

Or feel free to fill out the form below and someone from our team will follow-up with you.


  1. Cancer Statistics. (2020, September 25). National Cancer Institute, Retrieved Aug 4, 2021, from
  2. Samadder, et al. Comparison of Universal Genetic Testing vs Guideline-Directed Targeted Testing for PatientsWith Hereditary Cancer Syndrome. JAMA Oncology, 2020; DOI: 10.1001/jamaoncol.2020.6252 
  3. Dohany, et al. Hereditary cancer risk assessment using a chatbot in women presenting to obstetrics and gynecology practices across the U.S. [abstract]. In: Proceedings of the 2019 San Antonio Breast Cancer Symposium; 2019 Dec 10-14; San Antonio, TX. Philadelphia (PA):AACR; Cancer Res 2020;80(4 Suppl):Abstract nr P6-08-39;  
  4. Frezzo, T., et al. The genetic family history as a risk assessment tool in internal medicine. Genet Med 5, 84–91 (2003);
  5. DeFrancescoMS, et al. Hereditary Cancer Risk Assessment and Genetic Testing in the Community-Practice Setting.Obstet Gynecol. 2018 Nov;132(5):1121-1129;  
  6. Hereditary Cancer Syndromes and Risk Assessment: ACOG COMMITTEE OPINION SUMMARY, Number 793.ObstetGynecol. 2019 Dec;134(6):1366-1367. doi: 10.1097/AOG.0000000000003563. PMID: 31764755.