Hereditary Cancer Genetic Testing Results

Support throughout your hereditary cancer testing process

 

We believe that knowledge is power. We are here to help you understand what your genetic information means for you and your family members.

What are the possible results?

 

Positive

A positive result means that testing identified at least one harmful genetic change in a gene that is associated with increased risk for developing cancer. Such genetic changes are referred to as a pathogenic or likely pathogenic variant on your genetic test report. In some cases, an individual who has only one pathogenic or likely pathogenic variant in a gene is not expected to have an increased risk of developing cancer.

Negative

This means that the test did not identify any known genetic changes associated with an increased risk of developing cancer.*

Variant of Uncertain Significance (VUS)

This means that testing identified a genetic change, but scientists don’t currently know enough to determine if this variant is associated with an increased risk of cancer. While more information may be available in the future, it is important to understand that you will continue to be cared for based on your personal and family history in these cases.

Follow-up testing of specific biological relatives of an individual with a VUS can sometimes clarify the clinical significance of a VUS. Visit our Family Variant Testing program page to learn more.

Why does sharing my genetic test result with family members matter?

If your test result is positive, genetic testing may be indicated for your biological family members to determine if they carry the same pathogenic variant as you. Your test result is a piece of powerful information that can help both you and your family better understand cancer risks. Your test result can also help you and your family members make informed healthcare decisions with appropriate healthcare providers.

Starting the conversation about genetic testing with your family members can help them understand the importance of this information. In some cases, your family members’ genetic test result may enable them to take steps to reduce their cancer risk or detect cancer at an earlier, more treatable stage.

Sharing this type of information is important, but keep in mind that your relatives’ views about health and cancer may differ from your own.

 


 

Next steps

 

  1. Think about which family members you would like to share your results with (i.e., biological relatives)
  2. Download a sample letter you can send to a family member
  3. Give them a copy of your test results and share this link so they can learn more about hereditary cancer genetic testing
  4. Learn more about Family Variant Testing

 


 

Additional resources

 

> To find a genetic counselor, visit https://www.nsgc.org/findageneticcounselor
> National Cancer Institute https://www.cancer.gov
> Genetic Information Nondiscrimination Act (GINA) http://ginahelp.org

*The type of cancer, level of risks, and medical management recommendations will depend on your specific genetic test result. A negative result does not rule out the chance to develop cancer, and individuals with a negative result will still need screening based on family history or general population risks.

 

Still have questions?

Our customer service team is available to answer any questions you may have. Call us directly at 888-729-1206 (option 3), or email support@genedx.com.