Sema4 Signal® Hereditary Cancer

Family Variant Testing for Hereditary Cancer

Follow-up Hereditary Cancer Testing for Blood Relatives

Genetic test results may have health implications for individuals in the same family. If someone in your family received a positive test result, you may consider having genetic testing to determine if you have the same variant. Your result may provide you with important information about your cancer and/or reproductive risks.

For certain genes, having this information can also help guide you and your healthcare providers to make informed decisions about cancer screening, prevention, and/or treatment.


Eligibility

If Sema4 testing indicates a patient has a pathogenic or likely pathogenic variant, Sema4 will test their biological relatives for that same variant at no additional charge.

  • Patient has a first-, second-, or third-degree blood relative (such as sibling, parent, child, grandparent, or cousin) who had hereditary cancer genetic testing through Sema4 and was found to carry a pathogenic or likely pathogenic variant.
  • Family variant testing order is placed within 90 days of the original family member’s report.


Next Steps to Consider

  • Watch the hereditary cancer pre-test educational video below
  • If you would like to pursue genetic testing, bring your relative’s genetic test report to an appointment with your healthcare provider. Your provider will review your personal and family history before discussing appropriate genetic test options.
  • To find a genetic counselor in your area by visiting the National Society of Genetic Counselors

Pre-test educational video

If your doctor determines that a hereditary cancer test is right for you, he or she may ask you to watch this informational video to learn more about the testing process.


Frequently Asked Questions

I found out I have a pathogenic or likely pathogenic variant, should I tell my family?

It can be important to share your test results with your blood relatives. If you were found to carry a genetic variant associated with increased risk to develop cancer, your family members may also carry the same variant.

If you have a positive genetic test result, Sema4 has a program that can help your family members get testing for the same genetic variant.

For individuals with a positive finding, the test result contains a sample message you can send your family members.

What is family variant (or “cascade”) testing?

Genetics run in families – if a patient is found to carry a genetic variant associated with increased risk of developing cancer, their blood relatives may also carry the same variant. The family variant testing program is designed to provide access to testing to those blood relatives, to empower them with information about their cancer and/or reproductive risks.

For certain genes, having this information can help guide their healthcare providers to make informed decisions about cancer screening, prevention, and/or treatment.

Who is eligible for family variant testing?

If Sema4 hereditary cancer testing indicates a patient has a pathogenic or likely pathogenic variant, Sema4 makes targeted variant testing available to their first-, second-, or third-degree blood relatives (such as siblings, parents, children, grandparents, or cousins) at no additional charge. The test must be ordered within 90 days of the original family member’s report.

How do I order family variant testing?

Bring a copy of your relative’s genetic testing report to an appointment with your healthcare provider. Your provider will review your personal and family history of cancer before discussing appropriate genetic testing options.

Ready to Learn More?

Kindly fill out the form below and we’ll schedule a time to discuss your needs. Or feel free to call us at 833-486-6260.