Sema4 Signal® Hereditary Cancer

Family Variant Testing for Hereditary Cancer


Most cancers develop by chance in an individual and are not due to an inherited cause. However, about 5% to 10% of cancers are thought to be caused by inherited genetic changes (called pathogenic or likely pathogenic variants). These variants can be passed down in families. If your family member tested positive for a pathogenic variant, you may have an increased chance of having the same variant.

Follow up hereditary cancer testing for blood relatives

Genetic test results may have health implications for individuals in the same family. If someone in your family received a positive test result, you may consider having genetic testing to determine if you have the same variant. Your result may provide you with important information about your cancer and/or reproductive risks. For certain genes, having this information can also help guide you and your healthcare providers to make informed decisions about cancer screening, prevention, and/or treatment.



Next Steps to Consider

  • Watch the hereditary cancer pre-test educational video below

  • If you would like to pursue genetic testing, bring your relative’s genetic test report to an appointment with your healthcare provider. Your provider will review your personal and family history before discussing appropriate genetic test options.

  • To find a genetic counselor in your area by visiting the National Society of Genetic Counselors

Pre-test educational video

If your doctor determines that a hereditary cancer test is right for you, he or she may ask you to watch this informational video to learn more about the testing process.



Sema4 Signal Family variant (cascade) testing


Sema4 Signal offers hereditary cancer genetic testing for biological relatives of patients who are found to have a pathogenic or likely pathogenic variant at Sema4. We offer resources to support cascade (targeted variant) testing and family education to these individuals.

Eligibility & requirements

  • Patient has a first-degree or second-degree blood relative (such as brother/sister, mother/father, son/daughter, grandmother/grandfather) who had hereditary cancer genetic testing and was found to carry a pathogenic or likely pathogenic variant through Sema4
  • Eligibility and requirements apply to hereditary cancer genetic testing only


Ready to Learn More?

Kindly fill out the form below and we’ll schedule a time to discuss your needs. Or feel free to call us at 833-486-6260.