Sema4 Signal® Hereditary Cancer
Family Variant Testing for Hereditary Cancer
Most cancers develop by chance in an individual and are not due to an inherited cause. However, about 5% to 10% of cancers are thought to be caused by inherited genetic changes (called pathogenic or likely pathogenic variants). These variants can be passed down in families. If your family member tested positive for a pathogenic variant, you may have an increased chance of having the same variant.
Next Steps to Consider
Watch the hereditary cancer pre-test educational video below
If you would like to pursue genetic testing, bring your relative’s genetic test report to an appointment with your healthcare provider. Your provider will review your personal and family history before discussing appropriate genetic test options.
To find a genetic counselor in your area by visiting the National Society of Genetic Counselors
Sema4 Signal Family variant (cascade) testing
Sema4 Signal offers hereditary cancer genetic testing for biological relatives of patients who are found to have a pathogenic or likely pathogenic variant at Sema4. We offer resources to support cascade (targeted variant) testing and family education to these individuals.
Eligibility & requirements
- Patient has a first-degree or second-degree blood relative (such as brother/sister, mother/father, son/daughter, grandmother/grandfather) who had hereditary cancer genetic testing and was found to carry a pathogenic or likely pathogenic variant through Sema4
- Eligibility and requirements apply to hereditary cancer genetic testing only