Supporting your practice and patients with identifying and managing hereditary cancer

As a trusted partner for hereditary cancer solutions, Sema4 provides testing tools and support to help you implement a hereditary cancer risk assessment program at your practice. From family history screening to patient financial support and genetic counseling, our solutions will help you identify patients who are appropriate for testing and ensure those in need of further surveillance are not missed. View our provider brochure below for more information.

Hereditary cancer testing is crucial for
stratifying risk and improving outcomes

Hereditary cancer testing is paramount for the early detection of certain cancers. Approximately 1 in every 4 women who visit an OB/GYN meet guideline criteria for further evaluation and testing^1-3. By incorporating a hereditary cancer testing program into your practice, you can help patients with a personal or family history of heritable cancer understand their risk so that risk-reducing medical management decisions can be made to improve their health.

Choosing Sema4 Signal Hereditary Cancer for your practice

Sema4 Signal Hereditary Cancer offers a holistic approach to support OB/GYNs with the identification and management of patients at risk for hereditary cancer.

At Sema4, we believe that genetic counseling plays an important role in supporting and educating patients throughout the testing process. Our experienced, board-certified genetic counselors are available for all positive results and variants of uncertain significance (VUS). If your patient goes through genetic counseling, you will receive detailed consultation notes via EMR, portal, or fax, that summarize the session.

Connect with us today to discuss how we can integrate our high-quality testing and best-in-class services into your practice.

Panel Options

Our panels include all hereditary cancer genes with guideline-based risk and management recommendations, to ensure a comprehensive screening. For OB/GYN practices, the most frequently ordered Sema4 Signal Hereditary Cancer panel is our 38-gene High Prevalence Panel, which has been carefully curated to cover well-documented genes linked to multiple cancer types.

High Prevalence Panel:

• • • 38 genes associated with the most common cancer types, including breast, colon, ovarian, pancreatic, prostate, renal, uterine, and other cancers

• • • All genes are either guideline-driven or have well-established evidence of increased risk for common cancers

• • • Majority of genes are clinically actionable

Comprehensive Panel:

• • • 73 Genes associated with known or possible increased risk of hereditary cancer across the major organ systems

Universal Panel:

• • • 107 Genes associated with known or possible increased risk of hereditary cancer across the major organ systems*

• • • One of the most comprehensive hereditary cancer testing panel available for patients with a family history of multiple cancers

We also offer a range of other panels that may be appropriate for your patients. In total, Sema4 Signal Hereditary Cancer can screen for up to 113 genes across 17 different panel sizes. View our Panel Guide for full details on all Sema4 Signal Hereditary Cancer panels.

Best-in-class support and service, every step of the way

Our comprehensive workflow options can seamlessly integrate with your practice and our highly knowledgeable team is dedicated to partnering with practices such as yours to deliver the best possible care to patients.

Provider Support

• Flexible ordering and workflow integrations
• Industry-standard turnaround time of 14-21 days
• In-depth reporting of results, actionable findings, and VUS reclassifications
• Post-test counseling for patients with non-negative results

Patient Support

• Board-certified genetic counselors
• Pre- and post-test videos developed by our genetic counselors for patient education and support
• Extensive network coverage, benefits investigation and patient financial support
• Commitment to helping patients understand testing and implications for the prevention and active management of cancer

Advanced testing technology developed by industry-leading experts

Sema4 Signal Hereditary Cancer is delivered via our NGS-based >6,000 gene medical exome platform, Sema4 Signal Traversa^TM , with clinical biobanking to support future testing. Multiple analysis methods are used to ensure the highest detection rate for every gene on our panels.

Getting Started

When to order Sema4 Signal Hereditary Cancer

• Patient presents with a personal or family cancer history suspicious of a hereditary cancer syndrome
• Patient receives Family History Questionnaire result of “at risk” or “more information needed”

Ordering options available via Provider Portal or paper

• In-office testing is available. Please contact us for more information.
• At-home testing is also available for patients unable to see their provider in person. Learn more.