Sema4 Signal® Hereditary Cancer

Empowering health decisions with genetic testing


What is hereditary cancer?

Most cancers develop by chance in an individual and are not due to an inherited cause. However, about 5% to 10% of cancers are thought to be caused by inherited genetic changes (called pathogenic or likely pathogenic variants). These variants can be passed down in families.

Genetic testing can help you learn more about your risk of developing hereditary cancers. Knowing your risks can help you and your doctor establish a personalized medical management plan. For some individuals, this might include increased cancer screening or interventions that can lower the risk of developing cancers.


How might hereditary cancer genetic testing help me and my family?

Depending on the gene, testing positive for a pathogenic variant could mean that you have an increased risk of developing certain types of cancers. Because pathogenic variants often run in families, your relatives may also have inherited the same variant. Genetic testing can help you and your family members:

  • Take steps to detect cancer early/lower the risk of developing certain cancers
  • Determine the best treatment approach if cancer occurs
  • Identify if there is an inherited risk to develop cancer in a family so that relatives can make an informed decision about genetic testing


I have cancer (or had cancer before). Should I still be tested?

You can still benefit from hereditary cancer genetic testing even if you currently have cancer or have been diagnosed with cancer in the past. Genetic testing can help identify underlying hereditary causes of your cancer. This test might help you and your healthcare provider:

  • Better understand your risk of developing additional cancer(s)
  • Identify strategies to reduce the risk of developing additional cancer(s)
  • Take steps to detect cancer early. Early detection may help improve outcomes
  • Determine the best treatment approach for certain types of cancers
  • What can positive results mean for you and your family? Learn more.

“Knowing your health, knowing that you have these risk factors, that is powerful information for you to have as a patient in order to move forward and have control of your health versus your health having control of you.”


Jennifer Reynolds, Founder of Pink Warrior Advocates


What are some things I can do?

Find out if hereditary cancer genetic testing is
right for you with some of our resources below:


Hereditary Cancer
Family History Questionnaire

Designed to help you assess your risk of hereditary cancer. Should only take a few minutes to complete.

Start Questionnaire

Pre-test educational video

If your doctor determines that a hereditary cancer test is right for you, he or she may ask you to watch this informational video to learn more about the testing process.


We’re here to help


Our Sema4 Signal Patient Portal supports you along the journey, allowing you to:

Schedule genetic counseling appointments
View educational videos; and
Access your easy-to-understand test results report.



Still have questions?

Kindly fill out the form below and we’ll schedule a time to discuss your needs. Or feel free to call us at 833-486-6260.