Sema4 Signal® Hereditary Cancer
Facts about hereditary cancer:
- Studies have shown that 1 in 8 cancer diagnoses may be associated with a hereditary cause2
- 1 in 5 patients have a personal or family history suggestive of hereditary cancer3-5
- Most individuals with hereditary cancer have a 50% chance to pass the genetic variant to their children6
What is hereditary cancer testing and why is it important?
Genetic testing for hereditary cancer is a way to examine your DNA for certain gene variants that have been shown to increase the likelihood of developing cancer. Knowing your hereditary cancer risk can help you take steps to better prevent, detect, or treat certain cancers.
Jennifer Reynolds, founder of Pink Warrior Advocates, discusses her experience with a late-stage breast cancer diagnosis, the importance of proactive screening, and the impact it has had on her life.
- Cancer Statistics. (2020, September 25). National Cancer Institute, Retrieved Aug 4, 2021, from www.cancer.gov/about-cancer/understanding/statistics.
- Samadder, et al. Comparison of Universal Genetic Testing vs Guideline-Directed Targeted Testing for PatientsWith Hereditary Cancer Syndrome. JAMA Oncology, 2020; DOI: 10.1001/jamaoncol.2020.6252
- Dohany, et al. Hereditary cancer risk assessment using a chatbot in women presenting to obstetrics and gynecology practices across the U.S. [abstract]. In: Proceedings of the 2019 San Antonio Breast Cancer Symposium; 2019 Dec 10-14; San Antonio, TX. Philadelphia (PA):AACR; Cancer Res 2020;80(4 Suppl):Abstract nr P6-08-39;
- Frezzo, T., et al. The genetic family history as a risk assessment tool in internal medicine. Genet Med 5, 84–91 (2003);
- DeFrancescoMS, et al. Hereditary Cancer Risk Assessment and Genetic Testing in the Community-Practice Setting.Obstet Gynecol. 2018 Nov;132(5):1121-1129;
- Hereditary Cancer Syndromes and Risk Assessment: ACOG COMMITTEE OPINION SUMMARY, Number 793.ObstetGynecol. 2019 Dec;134(6):1366-1367. doi: 10.1097/AOG.0000000000003563. PMID: 31764755.