Sema4 Signal® Hereditary Cancer

Supporting your needs


At Sema4, we believe that every provider and patient should be able to easily access hereditary cancer testing, without logistical or financial barriers. That is why we pride ourselves on our in best-in-class services and support, which help make genetic testing accessible for all. From patient identification to post-test genetic counseling and educational support, delivered via our Sema4 Traversa™ genomic platform, we offer customizable solutions to meet the unique needs of your practice and patients.

Genetic counseling support

  • Experienced, board-certified Sema4 counselors
  • For all positive results and variants of uncertain significance (VUS)
  • Notes, including family pedigree and management recommendations, delivered via EMR, portal, or fax

Patient identification and education tools

Extensive network coverage and supportive billing

  • For providers: Assistance to obtain pre-authorization and appeal coverage
  • For patients: Outreach if the out-of-pocket cost is expected to exceed $99, competitive cash price, payment plans, and financial assistance programs

Seamless workflow integration

  • Integration with EMR, Sema4 Provider Portal, and paper
  • Digital tools and services support easy ordering, consenting, sample tracking, resulting, and counseling

Additional features

  • Saliva test kits can be sent direct to patient’s home to avoid the need for an in-office blood draw. Learn more
  • Reflex testing to meet patients’ needs
  • Upgrade (re-requisition) of panels within 120 days of initial sample receipt at no additional cost
  • Family variant (cascade) testing: Resources to support testing and education of first- and second-degree family members. Learn more about family variant testing.
  • Sema4 Signal VUS Resolution Program: Research-based testing of eligible family members to help clarify the nature of VUS. Learn more
  • Biobanking of patient’s DNA for future testing



Clinical decision support tools


Comprehensive, easy-to-read report

  • Results explained in a patient-friendly way
  • Includes positive results, negative results, and VUS
  • Guideline-driven medical management recommendations, where appropriate
  • Accessible via the Sema4 Provider Portal

Sema4 Provider Portal

  • Streamlined workflow integration
  • Enables simplified ordering, sample tracking, and access to results


Additional Resources


How can we help?

Feel free to call us at 833-486-6260 or fill out the form below and we’ll schedule a time to discuss your needs.