BRAF gene mutations are found in many different cancers, including malignant melanomas (27-70%), papillary thyroid cancers (36-53%), colorectal cancers (5-22%), hairy cell leukemias (100%), and serous ovarian cancers (30%). The V600E mutation predominates, being found in about 86% of BRAF mutations in cancer. V600K accounts for about 12% of BRAF mutations. Other mutations in BRAF have been identified, but are extremely rare. Mutations in BRAF predict response to BRAF inhibitors in melanoma