Sema4 Signal Gene Card

 

The Sema4 Signal WES/WTS and PanCancer Gene card is designed as a convenient online search tool to learn more about critical-cancer associated genes involved in the WES/WTS and PanCancer tests. The WES/WTS and PanCancer Gene card highlights frequently altered, clinically significant genes that have FDA-approved therapies and/or have a strong and established footprint in specific cancer types. The gene card features 361 genes from the 2197 PanCancer gene panel. Simply search by Organ/Tissue, Tumor Type, or Associated Gene in the search field below.

 

Type of malignancyOrgan/TissueTumor TypeAssociated Genes
SolidBladderBladder urothelial carcinomaAPC, ARID1A, ASXL2, ATM, BAP1, BRCA1, BRCA2, CCND1, CDKN1A, CDKN2A, CDKN2B, CIC, CREBBP, CTNNB1, E2F3, ELF3, EP300, ERBB2, ERBB3, ERCC2, FAT1, FBXW7, FGFR2, FGFR3, FOXA1, GATA3, IGF1R, KDM6A, KMT2A, KMT2C, KMT2D, KRAS, MDM2, MTOR, MUC1, MYC, NF1, NFE2L2, NTRK1, NTRK2, NTRK3, PIK3CA, POLE, PTEN, RB1, SPTAN1, STAG2, TERT, TP53, TSC1
SolidBreastBreast adenocarinomaAFF2, AKT1, ARID1A, BRCA1, BRCA2, CBFB, CCND1, CCND3, CDH1, CDK4, CDK6, CDKN1B, CHEK2, ERBB2, ESR1, FGFR1, FGFR2, FH, FOXA1, FOXM1, GATA3, GNAS, IGFR1, KIT, MAP2K4, MAP3K1, MET, MUC1, MUC4, MYC, NBN, NF1, NTRK1, NTRK2, NTRK3, PARP1, PDGFRA, PIK3CA, PIK3R1, PTEN, PTPN22, PTPRD, RAD51C, RUNX1, SF3B1, TP53
SolidBrainGlioblastoma MultiformeARID5B, BRAF, CDK4, CDKN2A, CDKN2B, CHIC2, DDIT3, EGFR, ERRFI1, FAT1, FGFR3, GATA3, GLI1, IDH1, IDH2, KDR, KIT, KMT2D, KRAS, LZTR1, MDM2, MET, MGMT, NF1, NTRK1, NTRK2, NTRK3, PDGFRA, PIK3CA, PIK3R1, PTEN, RB1, TERT, TP53
SolidBrainGliomaATRX, EGFR, IDH1, NF1, PIK3CA, PTEN, TP53, TERT, PIK3R1, RB1, CDKN2A, CDK4, NTRK1, NTRK2, NTRK3
SolidBrainMedulloblastomaCTNNB1, KDM6A, PTCH1
SolidBrainOligodendrogliomaARID1A, ARID1B, CIC, FUBP1, IDH1, IDH2, NF1, NOTCH1, PIK3CA, PIK3R1, SETD2, SMARCA4, SOX2, TERT
SolidBrainAnaplastic AstrocytomaATRX, CDK4, CDKN2A, CDKN2B, EGFR, FAT1, GLI1, IDH1, KDR, KIT, MDM2, MDM4, NF1, PDGFRA, PIK3CA, PIK3R1, PTEN, PTPN11, SMARCA4, SOX2, TERT, TP53
SolidBoneChondrosarcomaARID1A, ATRX, CDKN2A, EWSR1, IDH1, NR4A3, TERT, TP53
SolidBoneEwing’s SarcomaBRCA2, CCND1, CDKN2A, ERG, EWSR1, FAT1, FLI1, SMARCA4, STAG2, TP53
SolidBoneOsteosarcomaATRX, AURKA, CALR, CCND3, CCNE1, CDK4, CDKN2A, CDKN2B, DNMT1, FLCN, GLI1, INSR, KDR, KEAP1, KIT, MAP2K4, MCL1, MDM2, NCOR1, PDGFRA, PLCG2, PTCH1, RAD21, RB1, SMAD2, SMARCA4, TP53, VEGFA
SolidBowelColorectal adenocarcinomaACVR1B, ACVR2A, APC, ARID1A, ATM, BRAF, BRCA2, CASP8, CDC27, CTNNB1, ERBB2, ERBB3, FBXW7, FHIT, FLT3, GNAS, KRAS, MSH3, MSH6, MTOR, MYC, NOTCH1, NRAS, NTRK1, NTRK2, NTRK3, PIK3CA, POLE, PTEN, ROS1, RSPO2, RSPO3, SMAD2, SMAD4, SOX9, SRC, TCF7L2, TGFBR2, TP53
SolidBowelAnal squamous cell carcinomaARID1A, CREBBP, FAT1, KMT2D, NF1, NFE2L2, NOTCH2, NTRK1, NTRK2, NTRK3, PIK3CA, PTEN, SOX2, STK11, TP53, TP63
SolidCervixCervical squamous cell carcinomaAKT1, AR, ARID1A, ATR, CASP8, CDKN1A, CHEK1, DNMT1, EP300, ERBB2, ERBB3, EZH2, FANCA, FAT1, FBXW7, FGFR3, GSK3B, HLA-A, HLA-B, KDR, KMT2D, KRAS, MAPK1, NFE2L2, NOTCH1, NOTCH3, NSD1, PGR, PIK3CA, POLE, PTEN, RB1, REL, SKP2, SOX2, STK11, TERT, TGFBR2, TP53, TP63, YAP1
SolidEsophagus / StomachEsophageal adenocarcinomaAPC, AR, ARID1A, ATM, CCND1, CCNE1, CDK6, CDKN2A, CTNNB1, EGFR, ERBB2, ERBB3, ERBB4, GATA4, GATA6, KRAS, MTOR, MUC4, MYC, NOTCH1, PIK3CA, SMAD4, TP53, VEGFA
SolidEsophagus / StomachStomach adenocarcinomaAPC, AR, ARID1A, ATM, B2M, BCOR, BRCA2, CCND1, CCNE1, CDH1, CDK6, CDK12, CDKN2A, CTNNB1, EGFR, ERBB2, ERBB3, ERBB4, FBXW7, FGFR2, FHIT, GATA4, GATA6, GLI1, GNAS, HLA-A, HLA-B, KRAS, MET, MLH1, MSH6, MTOR, MUC4, MYC, NF1, NOTCH1, NTRK1, NTRK2, NTRK3, PIK3CA, PIK3R1, POLE, PTEN, RASA1, RHOA, RNF43, SALL4, SMAD4, SOX2, TERT, TP53, VEGFA, ZNF217
SolidHead and NeckHead and neck squamous cell carcinomaARID1A, ATR, CASP8, CCND1, CDK6, CDKN2A, CDKN2B, E2F1, EGFR, EP300, ERBB2, FAT1, FBXW7, FGF3, FGFR1, FGFR3, HLA-A, HRAS, KMT2D, MAPK1, MET, MYC, NFE2L2, NOTCH1, NOTCH2, NOTCH3, NSD1, NTRK1, NTRK2, NTRK3, PIK3CA, PTEN, RB1, SMAD4, SOX2, TERT, TGFBR2, TP53, TP63, TRAF3, YAP1, ZNF750
SolidHead and NeckSalivary gland cancerCDKN2A, CDKN2B, ERBB2, ETV6, KDM6A, KIT, KMT2D, MGA, RUNX1, TP53, NOTCH1, ARID1A, PIK3CA, TERT, NTRK3, NF1, PDGFRA, NTRK1, NTRK2
SolidKidneyRenal cell carcinomaARID1A, ASXL1, BAP1, CDKN2A, CDKN2B, CTNNB1, FAT1, FLT4, KDM5C, KDM6A, MET, MLH1, MTOR, NF1, NF2, NFE2L2, PBRM1, PDGFRB, PIK3CA, PTEN, RAF1, RHOA, SETD2, SMARCB1, STAG2, TERT, TGFBR2, TP53, VHL
SolidLiverHepatocellular carcinomaALB, APOB, ARID1A, ARID2, AXIN1, BAP1, CCND1, CDKN2A, CTNNB1, EEF1A1, EIF3E, FGF19, FGF3, FGF4, HEY1, IDH1, JAK1, KEAP1, LZTR1, MCL1, MDM4, MET, MUC1, MYC, NDRG1, NFE2L2, NOTCH2, PTEN, RB1, SETD2, SF3B1, SMARCA4, SMYD3, TERT, TP53, TPM3, TSC2, VEGFA
SolidGall bladder, bile ductCholangiocarcinomaALB, APC, ARAF, ARID1A, ARID1B, ATM, BAP1, BRAF, BRCA2, CCND1, CDK4, CDKN2A, CDKN2B, ELF3, ERBB2, FGFR2, IDH1, IDH2, KDR, KMT2C, KRAS, MCL1, MDM2, MUC1, MUC4, MYC, NF1, NOTCH2, PBRM1, PIK3CA, PIK3R1, POLE, PTEN, ROS1, SMAD4, STK11, TP53
SolidLungNon-small cell lung cancerAKT1, ALK, ARAF, ARID1A, ATM, ATR, BRAF, BRCA1, BRCA2, CCND1, CCNE1, CDKN2A, CDKN2B, DROSHA, EGFR, ERBB2, ERBB4, FBXW7, FGFR1, HGF, KDR, KEAP1, KRAS, MAP2K1, MDM2, MET, MTOR, MYC, NF1, NFE2L2, NKX2-1, NOTCH1, NRG1, NTRK1, NTRK2, NTRK3, PDGFRA, PIK3CA, POLE, PTEN, RB1, RBM10, RET, RIT1, ROS1, SETD2, SMARCA4, STK11, TP53, U2AF1, ZEB1
SolidOvaryOvarian epithelial tumorARID1A, BRCA1, BRCA2, CCNE1, CDK12, CSMD3, FOXM1, GABRA6, KRAS, MYC, NF1, PIK3CA, PTEN, RB1, RECQL4, TERT, TP53
SolidPancreasPancreatic adenocarcinomaAKT2, ARID1A, BRCA1, BRCA2, CDH17, CDKN2A, CDKN2B, CTNNB1, EPCAM, ERBB2, FGFR1, FGFR4, GNAS, JAK1, KDM6A, KRAS, MLH1, MSH2, MSH6, MUC16, MYC, NF1, NOTCH2, NTRK1, NTRK2, NTRK3, PALB2, PBRM1, PMS2, PRSS1, RNF43, RREB1, SMAD4, SPRED1, TGFBR2, TP53
SolidProstateProstate adenocarcinomaAKT1, AR, ATM, BARD1, BRAF, BRCA1, BRCA2, BRIP1, CCND1, CDH1, CDK12, CHEK1, CHEK2, CTNNB1, ERG, ETV1, ETV4, FANCL, FLI1, FOXA1, HRAS, IDH1, KDM6A, KMT2D, MED12, MYC, PALB2, PIK3CA, PTEN, RAD51B, RAD51C, RAD51D, RAD54L, RB1, SPINK1, SPOP, TERT, TMPRSS2, TP53
SolidSkinCutaneous melanomaARID2, BRAF, CCND1, CDK4, CDKN2A, CDKN2B, COL1A1, CTNNB1, ERBB4, EZH2, FLT1, FLT3, GNA11, GNAQ, GRIN2A, IDH1, KDR, KIT, LCK, MAP2K1, MET, MTOR, MUC4, NF1, NOTCH2, NRAS, NTRK1, NTRK2, NTRK3, PDGFRA, PPP6C, PREX2, PTEN, RAC1, RB1, ROS1, RPS27, SMARCA4, TERT, TNC, TP53, TP63, ZEB1
SolidSoft TissueGastrointestinal stromal tumorCDKN2A, CDKN2B, KIT, NF1, PDGFRA, RB1, TP53
SolidSoft TissueSarcomasALK, APC, ARID1A, ARID1B, ARID2, ATM, ATRX, BIRC3, BRCA2, CCDN2, CCNE1, CDK4, CDKN2A, CDKN2B, CEBPA, CIC, CREBBP, DDIT3, DICER1, DNMT3A, EP300, EPHA5, EWSR1, FANCC, FAT1, FGFR1, FLCN, FRS2, GLI1, HMGA2, IDH1, IFNGR1, IGF1R, JUN, KIT, KMT2A, KMT2B, KMT2C, KMT2D, KRAS, LATS1, MAP2K4, MAP4K1, MCL1, MDM2, MTOR, NAB2, NF1, NF2, NOTCH2, NSD1, PBRM1, PDGFRA, PIK3CA, PRKDC, PTEN, PTPRQ, RB1, RET, SDHA, SMARCB1, STAT6, TERT, TNFAIP3, TP53, WT1, YAP1, ZFHX3
SolidThyroidPapillary thyroid cancerAKT1, ARID1B, BRAF, CHEK2, EIF1AX, HRAS, KMT2C, KRAS, MEN1, NF1, NF2, NRAS, NTRK1, NTRK2, NTRK3, PAX8, PIK3CA, PPARG, PPM1D, RB1, RBM10, RET, TERT, TP53
SolidThyroidPoorly differentiated thyroid cancerAKT3, ARID1A, ARID1B, ARID2, ATM, BRAF, CDKN2A, DICER1, EIF1AX, HRAS, KMT2A, KRAS, MEN1, NKX2-1, NRAS, NTRK1, NTRK2, NTRK3, PIK3CA, PTEN, RB1, RBM10, RET, TERT, TP53
SolidThyroidAnaplastic thyroid cancerAPC, ARID1A, ATM, BRAF, CDKN1B, CDKN2A, CDKN2B, CREBBP, EIF1AX, EP300, GLI1, HRAS, KEAP1, KMT2A, KMT2D, MEN1, MSH6, MTOR, NF1, NF2, NRAS, PBRM1, PIK3CA, PTEN, RAC1, RB1, RET, SETD2, SMARCB1, TERT, TP53, TSC2, TSHR
SolidThyroidMedullary thyroid cancerALK, ARID1A, BLM, FLT1, FLT3, HRAS, IDH1, IKBKE, KDR, MDM4, MSH2, MTOR, NTRK1, NTRK2, NTRK3, POLE, RET, SMARCA4, TP53, WT1
SolidUterusEndometrial carcinomaARID1A, ARID5B, ATM, ATR, BRCA1, BRCA2, CCND1, CCNE1, CREBBP, CTNNB1, ERBB2, ERBB3, FBXW7, FGFR1, FGFR2, FGFR3, IGF1R, JAK1, JAK2, KDR, KIT, KRAS, LRP1B, MED12, MSH6, MTOR, MYC, NF1, NFE2L2, NOTCH3, NOTCH4, NTRK1, NTRK2, NTRK3, PIK3CA, PIK3R1, POLE, PPP2R1A, PTCH1, PTEN, RB1, RNF43, SMARCA4, SPOP, TP53, TSC2
HemeBloodAcute Myeloid Leukemia (AML)ABL1, ASXL1, CBFB, CEBPA, DEK, DNMT3A, FLT3, GATA2, IDH1, IDH2, KIT, KMT2A, KRAS, MAX, MECOM, MYC, NF1, NPM1, NRAS, NUP98, PDGFRA, PTPN11, RARA, RUNX1, SETBP1, SF3B1, SMC1A, SRSF2, STAG2, TET2, TP53, U2AF1, WT1, ZRSR2
HemeBloodMultiple Myeloma/Plasma Cell Myeloma (PCM)B2M, BRAF, CCND1, CDK4, DIS3, EGR1, FGFR3, IDH1, IDH2, KRAS, MAF, MAFB, MYD88, NRAS, PIK3CA, PTPN11, SF3B1, TP53, LRP1B, MUC16
HemeBloodMyeloproliferative Neoplasms (MPN)ASXL1, CALR, CBL, CSF3R, DNMT3A, EZH2, IDH1, IDH2, JAK2, MPL, PDGFRA, SF3B1, SH2B3, SRSF2, TET2, TP53, U2AF1, NFE2, NRAS, PPM1D, ZRSR2
HemeBloodMyelodysplastic Syndromes (MDS)ASXL1, BCOR, CALR, CBL, DNMT3A, EP300, ETV6, PDGFRB, EZH2, FLT3, GATA2, IDH1, IDH2, JAK2, KMT2C, KRAS, MPL, NF1, NPM1, NRAS, PHF6, PPM1D, RUNX1, SETBP1, SF3B1, SRSF2, STAG2, STAT3, TET2, TP53, U2AF1, WT1, ZRSR2, NSD1, KMT2A
HemeBloodChronic Myeloid Leukemia (CML)ABL1, ASXL1, DNMT3A, RUNX1, TET2
HemeBloodMyelodysplastic/Myeloproliferative Neoplasms (MDS/MPN)ASXL1, CALR, CBL, CUX1, ETNK1, JAK2, JAK3, KMT2D, KRAS, MPL, NF1, NRAS, PDGFRA, PDGFRB, PTPN11, RUNX1, SETBP1, SF3B1, SRSF2, TET2, U2AF1, ZRSR2, IDH2, STAG2
HemeBloodSystemic Mastocytosis (SM)ASXL1, CBL, PDGFRA, IDH1, JAK2, KIT, KRAS, NPM1, NRAS, RUNX1, SRSF2, TET2
HemeBloodChronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLLSLL)BIRC3, BRAF, BTK, CDKN2A, CDKN2B, KRAS, MYC, MYD88, NOTCH1, NRAS, PLCG2, SF3B1, TP53, XPO1, ATM
HemeBloodDiffuse Large B-Cell Lymphoma, NOS (DLBCLNOS)ARID1A, B2M, BCL2, BCL6, CARD11, CREBBP, EZH2, HIST1H1E, IRF4, KMT2D, MAP2K1, MYC, MYD88, NRAS, PIM1, SOCS1, TNFRSF14, TP53, BCL7A, MUC16, EP300, MUC4, IRF8, CSMD3, CXCR4, STAT6, LRP1B, FAT1, BTK, DTX1, FAT4, KIAA1549, MEF2B, ATM, BCR, BRCA2, GNA13, HIST1H1D, PTPRD, ARHGEF10, BIRC6, EBF1, KMT2C, NUP98, POU2AF1, PTCH1, ARID5B, CD79B, FGFR2, KMT2A, NOTCH3, PDE4DIP, PTPRK, SETD1B, ZFHX3
HemeBloodFollicular Lymphoma (FL)BCL2, BCL6, CREBBP, EP300, EZH2, IRF4, KMT2D, MAP2K1, MYD88, TNFRSF14, PIM1, TP53, HLA-B, TNFAIP3, HLA-A, B2M, BTG1, CD79B, DTX1, HIST1H1E, SOCS1, TBL1XR1, MEF2B, PRDM1, IRF8, SPEN, CCND3, SETD1B, SGK1, CD58, BCL10, FAS, ETV6, ARID1A, STAT3, NOTCH2, TET2, EBF1, GNA13, FOXO1, ANKRD11, NFKBIE, P2RY8, ARID1B, BCL7A, ACTG1, MYC, CDKN2A, PAX5, CIITA, BCOR, PDE4DIP, HIST1H1D
HemeBloodMarginal Zone Lymphoma (MZL)ARID1A, CARD11, CREBBP, KMT2A, KMT2D, MALT1, MYD88, NOTCH1, TET2
HemeBloodMantle Cell Lymphoma (MCL)CCND1, CCND2, TP53
HemeBloodBurkitt Lymphoma (BL)ARID1A, BCL2, BCL6, ID3, MYC, SMARCA4, TP53
HemeBloodWaldenstrom Macroglobulinemia/Lymphoplasmocytic Lymphoma (WM)ARID1A, CXCR4, MYD88
HemeBloodHairy Cell Leukemia (HCL)BRAF, CCND3, CDKN1B, KMT2C, MAP2K1, NF1, U2AF1
HemeBloodADULT ALL (BLL,TLL)ABL1, ABL2, CRLF2, CSF1R, EPOR, ETV6, FLT3, IKZF1, IL3, IL7R, JAK1, JAK2, JAK3, KMT2A, PDGFRB, SH2B3, TCF3, RUNX1
HemeBloodPEDIATRIC ALL (BLL, TLL)ABL1, ABL2, CDKN2A, CRLF2, CSF1R, EPOR, FGFR1, FLT3, IKZF1, IL3, IL7R, JAK1, JAK2, JAK3, KMT2A, PDGFRB, RUNX1, SH2B3, TCF3