Sema4 Signal Gene Card

 

The Sema4 Signal WES/WTS and PanCancer Gene card is designed as a convenient online search tool to learn more about critical-cancer associated genes involved in the WES/WTS and PanCancer tests. The WES/WTS and PanCancer Gene card highlights frequently altered, clinically significant genes that have FDA-approved therapies and/or have a strong and established footprint in specific cancer types. The gene card features 361 genes from the 2197 PanCancer gene panel. Simply search by Organ/Tissue, Tumor Type, or Associated Gene in the search field below.

 

Type of malignancy Organ/Tissue Tumor Type Associated Genes
Solid Bladder Bladder urothelial carcinoma APC, ARID1A, ASXL2, ATM, BAP1, BRCA1, BRCA2, CCND1, CDKN1A, CDKN2A, CDKN2B, CIC, CREBBP, CTNNB1, E2F3, ELF3, EP300, ERBB2, ERBB3, ERCC2, FAT1, FBXW7, FGFR2, FGFR3, FOXA1, GATA3, IGF1R, KDM6A, KMT2A, KMT2C, KMT2D, KRAS, MDM2, MTOR, MUC1, MYC, NF1, NFE2L2, NTRK1, NTRK2, NTRK3, PIK3CA, POLE, PTEN, RB1, SPTAN1, STAG2, TERT, TP53, TSC1
Solid Breast Breast adenocarinoma AFF2, AKT1, ARID1A, BRCA1, BRCA2, CBFB, CCND1, CCND3, CDH1, CDK4, CDK6, CDKN1B, CHEK2, ERBB2, ESR1, FGFR1, FGFR2, FH, FOXA1, FOXM1, GATA3, GNAS, IGFR1, KIT, MAP2K4, MAP3K1, MET, MUC1, MUC4, MYC, NBN, NF1, NTRK1, NTRK2, NTRK3, PARP1, PDGFRA, PIK3CA, PIK3R1, PTEN, PTPN22, PTPRD, RAD51C, RUNX1, SF3B1, TP53
Solid Brain Glioblastoma Multiforme ARID5B, BRAF, CDK4, CDKN2A, CDKN2B, CHIC2, DDIT3, EGFR, ERRFI1, FAT1, FGFR3, GATA3, GLI1, IDH1, IDH2, KDR, KIT, KMT2D, KRAS, LZTR1, MDM2, MET, MGMT, NF1, NTRK1, NTRK2, NTRK3, PDGFRA, PIK3CA, PIK3R1, PTEN, RB1, TERT, TP53
Solid Brain Glioma ATRX, EGFR, IDH1, NF1, PIK3CA, PTEN, TP53, TERT, PIK3R1, RB1, CDKN2A, CDK4, NTRK1, NTRK2, NTRK3
Solid Brain Medulloblastoma CTNNB1, KDM6A, PTCH1
Solid Brain Oligodendroglioma ARID1A, ARID1B, CIC, FUBP1, IDH1, IDH2, NF1, NOTCH1, PIK3CA, PIK3R1, SETD2, SMARCA4, SOX2, TERT
Solid Brain Anaplastic Astrocytoma ATRX, CDK4, CDKN2A, CDKN2B, EGFR, FAT1, GLI1, IDH1, KDR, KIT, MDM2, MDM4, NF1, PDGFRA, PIK3CA, PIK3R1, PTEN, PTPN11, SMARCA4, SOX2, TERT, TP53
Solid Bone Chondrosarcoma ARID1A, ATRX, CDKN2A, EWSR1, IDH1, NR4A3, TERT, TP53
Solid Bone Ewing’s Sarcoma BRCA2, CCND1, CDKN2A, ERG, EWSR1, FAT1, FLI1, SMARCA4, STAG2, TP53
Solid Bone Osteosarcoma ATRX, AURKA, CALR, CCND3, CCNE1, CDK4, CDKN2A, CDKN2B, DNMT1, FLCN, GLI1, INSR, KDR, KEAP1, KIT, MAP2K4, MCL1, MDM2, NCOR1, PDGFRA, PLCG2, PTCH1, RAD21, RB1, SMAD2, SMARCA4, TP53, VEGFA
Solid Bowel Colorectal adenocarcinoma ACVR1B, ACVR2A, APC, ARID1A, ATM, BRAF, BRCA2, CASP8, CDC27, CTNNB1, ERBB2, ERBB3, FBXW7, FHIT, FLT3, GNAS, KRAS, MSH3, MSH6, MTOR, MYC, NOTCH1, NRAS, NTRK1, NTRK2, NTRK3, PIK3CA, POLE, PTEN, ROS1, RSPO2, RSPO3, SMAD2, SMAD4, SOX9, SRC, TCF7L2, TGFBR2, TP53
Solid Bowel Anal squamous cell carcinoma ARID1A, CREBBP, FAT1, KMT2D, NF1, NFE2L2, NOTCH2, NTRK1, NTRK2, NTRK3, PIK3CA, PTEN, SOX2, STK11, TP53, TP63
Solid Cervix Cervical squamous cell carcinoma AKT1, AR, ARID1A, ATR, CASP8, CDKN1A, CHEK1, DNMT1, EP300, ERBB2, ERBB3, EZH2, FANCA, FAT1, FBXW7, FGFR3, GSK3B, HLA-A, HLA-B, KDR, KMT2D, KRAS, MAPK1, NFE2L2, NOTCH1, NOTCH3, NSD1, PGR, PIK3CA, POLE, PTEN, RB1, REL, SKP2, SOX2, STK11, TERT, TGFBR2, TP53, TP63, YAP1
Solid Esophagus / Stomach Esophageal adenocarcinoma APC, AR, ARID1A, ATM, CCND1, CCNE1, CDK6, CDKN2A, CTNNB1, EGFR, ERBB2, ERBB3, ERBB4, GATA4, GATA6, KRAS, MTOR, MUC4, MYC, NOTCH1, PIK3CA, SMAD4, TP53, VEGFA
Solid Esophagus / Stomach Stomach adenocarcinoma APC, AR, ARID1A, ATM, B2M, BCOR, BRCA2, CCND1, CCNE1, CDH1, CDK6, CDK12, CDKN2A, CTNNB1, EGFR, ERBB2, ERBB3, ERBB4, FBXW7, FGFR2, FHIT, GATA4, GATA6, GLI1, GNAS, HLA-A, HLA-B, KRAS, MET, MLH1, MSH6, MTOR, MUC4, MYC, NF1, NOTCH1, NTRK1, NTRK2, NTRK3, PIK3CA, PIK3R1, POLE, PTEN, RASA1, RHOA, RNF43, SALL4, SMAD4, SOX2, TERT, TP53, VEGFA, ZNF217
Solid Head and Neck Head and neck squamous cell carcinoma ARID1A, ATR, CASP8, CCND1, CDK6, CDKN2A, CDKN2B, E2F1, EGFR, EP300, ERBB2, FAT1, FBXW7, FGF3, FGFR1, FGFR3, HLA-A, HRAS, KMT2D, MAPK1, MET, MYC, NFE2L2, NOTCH1, NOTCH2, NOTCH3, NSD1, NTRK1, NTRK2, NTRK3, PIK3CA, PTEN, RB1, SMAD4, SOX2, TERT, TGFBR2, TP53, TP63, TRAF3, YAP1, ZNF750
Solid Head and Neck Salivary gland cancer CDKN2A, CDKN2B, ERBB2, ETV6, KDM6A, KIT, KMT2D, MGA, RUNX1, TP53, NOTCH1, ARID1A, PIK3CA, TERT, NTRK3, NF1, PDGFRA, NTRK1, NTRK2
Solid Kidney Renal cell carcinoma ARID1A, ASXL1, BAP1, CDKN2A, CDKN2B, CTNNB1, FAT1, FLT4, KDM5C, KDM6A, MET, MLH1, MTOR, NF1, NF2, NFE2L2, PBRM1, PDGFRB, PIK3CA, PTEN, RAF1, RHOA, SETD2, SMARCB1, STAG2, TERT, TGFBR2, TP53, VHL
Solid Liver Hepatocellular carcinoma ALB, APOB, ARID1A, ARID2, AXIN1, BAP1, CCND1, CDKN2A, CTNNB1, EEF1A1, EIF3E, FGF19, FGF3, FGF4, HEY1, IDH1, JAK1, KEAP1, LZTR1, MCL1, MDM4, MET, MUC1, MYC, NDRG1, NFE2L2, NOTCH2, PTEN, RB1, SETD2, SF3B1, SMARCA4, SMYD3, TERT, TP53, TPM3, TSC2, VEGFA
Solid Gall bladder, bile duct Cholangiocarcinoma ALB, APC, ARAF, ARID1A, ARID1B, ATM, BAP1, BRAF, BRCA2, CCND1, CDK4, CDKN2A, CDKN2B, ELF3, ERBB2, FGFR2, IDH1, IDH2, KDR, KMT2C, KRAS, MCL1, MDM2, MUC1, MUC4, MYC, NF1, NOTCH2, PBRM1, PIK3CA, PIK3R1, POLE, PTEN, ROS1, SMAD4, STK11, TP53
Solid Lung Non-small cell lung cancer AKT1, ALK, ARAF, ARID1A, ATM, ATR, BRAF, BRCA1, BRCA2, CCND1, CCNE1, CDKN2A, CDKN2B, DROSHA, EGFR, ERBB2, ERBB4, FBXW7, FGFR1, HGF, KDR, KEAP1, KRAS, MAP2K1, MDM2, MET, MTOR, MYC, NF1, NFE2L2, NKX2-1, NOTCH1, NRG1, NTRK1, NTRK2, NTRK3, PDGFRA, PIK3CA, POLE, PTEN, RB1, RBM10, RET, RIT1, ROS1, SETD2, SMARCA4, STK11, TP53, U2AF1, ZEB1
Solid Ovary Ovarian epithelial tumor ARID1A, BRCA1, BRCA2, CCNE1, CDK12, CSMD3, FOXM1, GABRA6, KRAS, MYC, NF1, PIK3CA, PTEN, RB1, RECQL4, TERT, TP53
Solid Pancreas Pancreatic adenocarcinoma AKT2, ARID1A, BRCA1, BRCA2, CDH17, CDKN2A, CDKN2B, CTNNB1, EPCAM, ERBB2, FGFR1, FGFR4, GNAS, JAK1, KDM6A, KRAS, MLH1, MSH2, MSH6, MUC16, MYC, NF1, NOTCH2, NTRK1, NTRK2, NTRK3, PALB2, PBRM1, PMS2, PRSS1, RNF43, RREB1, SMAD4, SPRED1, TGFBR2, TP53
Solid Prostate Prostate adenocarcinoma AKT1, AR, ATM, BARD1, BRAF, BRCA1, BRCA2, BRIP1, CCND1, CDH1, CDK12, CHEK1, CHEK2, CTNNB1, ERG, ETV1, ETV4, FANCL, FLI1, FOXA1, HRAS, IDH1, KDM6A, KMT2D, MED12, MYC, PALB2, PIK3CA, PTEN, RAD51B, RAD51C, RAD51D, RAD54L, RB1, SPINK1, SPOP, TERT, TMPRSS2, TP53
Solid Skin Cutaneous melanoma ARID2, BRAF, CCND1, CDK4, CDKN2A, CDKN2B, COL1A1, CTNNB1, ERBB4, EZH2, FLT1, FLT3, GNA11, GNAQ, GRIN2A, IDH1, KDR, KIT, LCK, MAP2K1, MET, MTOR, MUC4, NF1, NOTCH2, NRAS, NTRK1, NTRK2, NTRK3, PDGFRA, PPP6C, PREX2, PTEN, RAC1, RB1, ROS1, RPS27, SMARCA4, TERT, TNC, TP53, TP63, ZEB1
Solid Soft Tissue Gastrointestinal stromal tumor CDKN2A, CDKN2B, KIT, NF1, PDGFRA, RB1, TP53
Solid Soft Tissue Sarcomas ALK, APC, ARID1A, ARID1B, ARID2, ATM, ATRX, BIRC3, BRCA2, CCDN2, CCNE1, CDK4, CDKN2A, CDKN2B, CEBPA, CIC, CREBBP, DDIT3, DICER1, DNMT3A, EP300, EPHA5, EWSR1, FANCC, FAT1, FGFR1, FLCN, FRS2, GLI1, HMGA2, IDH1, IFNGR1, IGF1R, JUN, KIT, KMT2A, KMT2B, KMT2C, KMT2D, KRAS, LATS1, MAP2K4, MAP4K1, MCL1, MDM2, MTOR, NAB2, NF1, NF2, NOTCH2, NSD1, PBRM1, PDGFRA, PIK3CA, PRKDC, PTEN, PTPRQ, RB1, RET, SDHA, SMARCB1, STAT6, TERT, TNFAIP3, TP53, WT1, YAP1, ZFHX3
Solid Thyroid Papillary thyroid cancer AKT1, ARID1B, BRAF, CHEK2, EIF1AX, HRAS, KMT2C, KRAS, MEN1, NF1, NF2, NRAS, NTRK1, NTRK2, NTRK3, PAX8, PIK3CA, PPARG, PPM1D, RB1, RBM10, RET, TERT, TP53
Solid Thyroid Poorly differentiated thyroid cancer AKT3, ARID1A, ARID1B, ARID2, ATM, BRAF, CDKN2A, DICER1, EIF1AX, HRAS, KMT2A, KRAS, MEN1, NKX2-1, NRAS, NTRK1, NTRK2, NTRK3, PIK3CA, PTEN, RB1, RBM10, RET, TERT, TP53
Solid Thyroid Anaplastic thyroid cancer APC, ARID1A, ATM, BRAF, CDKN1B, CDKN2A, CDKN2B, CREBBP, EIF1AX, EP300, GLI1, HRAS, KEAP1, KMT2A, KMT2D, MEN1, MSH6, MTOR, NF1, NF2, NRAS, PBRM1, PIK3CA, PTEN, RAC1, RB1, RET, SETD2, SMARCB1, TERT, TP53, TSC2, TSHR
Solid Thyroid Medullary thyroid cancer ALK, ARID1A, BLM, FLT1, FLT3, HRAS, IDH1, IKBKE, KDR, MDM4, MSH2, MTOR, NTRK1, NTRK2, NTRK3, POLE, RET, SMARCA4, TP53, WT1
Solid Uterus Endometrial carcinoma ARID1A, ARID5B, ATM, ATR, BRCA1, BRCA2, CCND1, CCNE1, CREBBP, CTNNB1, ERBB2, ERBB3, FBXW7, FGFR1, FGFR2, FGFR3, IGF1R, JAK1, JAK2, KDR, KIT, KRAS, LRP1B, MED12, MSH6, MTOR, MYC, NF1, NFE2L2, NOTCH3, NOTCH4, NTRK1, NTRK2, NTRK3, PIK3CA, PIK3R1, POLE, PPP2R1A, PTCH1, PTEN, RB1, RNF43, SMARCA4, SPOP, TP53, TSC2
Heme Blood Acute Myeloid Leukemia (AML) ABL1, ASXL1, CBFB, CEBPA, DEK, DNMT3A, FLT3, GATA2, IDH1, IDH2, KIT, KMT2A, KRAS, MAX, MECOM, MYC, NF1, NPM1, NRAS, NUP98, PDGFRA, PTPN11, RARA, RUNX1, SETBP1, SF3B1, SMC1A, SRSF2, STAG2, TET2, TP53, U2AF1, WT1, ZRSR2
Heme Blood Multiple Myeloma/Plasma Cell Myeloma (PCM) B2M, BRAF, CCND1, CDK4, DIS3, EGR1, FGFR3, IDH1, IDH2, KRAS, MAF, MAFB, MYD88, NRAS, PIK3CA, PTPN11, SF3B1, TP53, LRP1B, MUC16
Heme Blood Myeloproliferative Neoplasms (MPN) ASXL1, CALR, CBL, CSF3R, DNMT3A, EZH2, IDH1, IDH2, JAK2, MPL, PDGFRA, SF3B1, SH2B3, SRSF2, TET2, TP53, U2AF1, NFE2, NRAS, PPM1D, ZRSR2
Heme Blood Myelodysplastic Syndromes (MDS) ASXL1, BCOR, CALR, CBL, DNMT3A, EP300, ETV6, PDGFRB, EZH2, FLT3, GATA2, IDH1, IDH2, JAK2, KMT2C, KRAS, MPL, NF1, NPM1, NRAS, PHF6, PPM1D, RUNX1, SETBP1, SF3B1, SRSF2, STAG2, STAT3, TET2, TP53, U2AF1, WT1, ZRSR2, NSD1, KMT2A
Heme Blood Chronic Myeloid Leukemia (CML) ABL1, ASXL1, DNMT3A, RUNX1, TET2
Heme Blood Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN) ASXL1, CALR, CBL, CUX1, ETNK1, JAK2, JAK3, KMT2D, KRAS, MPL, NF1, NRAS, PDGFRA, PDGFRB, PTPN11, RUNX1, SETBP1, SF3B1, SRSF2, TET2, U2AF1, ZRSR2, IDH2, STAG2
Heme Blood Systemic Mastocytosis (SM) ASXL1, CBL, PDGFRA, IDH1, JAK2, KIT, KRAS, NPM1, NRAS, RUNX1, SRSF2, TET2
Heme Blood Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLLSLL) BIRC3, BRAF, BTK, CDKN2A, CDKN2B, KRAS, MYC, MYD88, NOTCH1, NRAS, PLCG2, SF3B1, TP53, XPO1, ATM
Heme Blood Diffuse Large B-Cell Lymphoma, NOS (DLBCLNOS) ARID1A, B2M, BCL2, BCL6, CARD11, CREBBP, EZH2, HIST1H1E, IRF4, KMT2D, MAP2K1, MYC, MYD88, NRAS, PIM1, SOCS1, TNFRSF14, TP53, BCL7A, MUC16, EP300, MUC4, IRF8, CSMD3, CXCR4, STAT6, LRP1B, FAT1, BTK, DTX1, FAT4, KIAA1549, MEF2B, ATM, BCR, BRCA2, GNA13, HIST1H1D, PTPRD, ARHGEF10, BIRC6, EBF1, KMT2C, NUP98, POU2AF1, PTCH1, ARID5B, CD79B, FGFR2, KMT2A, NOTCH3, PDE4DIP, PTPRK, SETD1B, ZFHX3
Heme Blood Follicular Lymphoma (FL) BCL2, BCL6, CREBBP, EP300, EZH2, IRF4, KMT2D, MAP2K1, MYD88, TNFRSF14, PIM1, TP53, HLA-B, TNFAIP3, HLA-A, B2M, BTG1, CD79B, DTX1, HIST1H1E, SOCS1, TBL1XR1, MEF2B, PRDM1, IRF8, SPEN, CCND3, SETD1B, SGK1, CD58, BCL10, FAS, ETV6, ARID1A, STAT3, NOTCH2, TET2, EBF1, GNA13, FOXO1, ANKRD11, NFKBIE, P2RY8, ARID1B, BCL7A, ACTG1, MYC, CDKN2A, PAX5, CIITA, BCOR, PDE4DIP, HIST1H1D
Heme Blood Marginal Zone Lymphoma (MZL) ARID1A, CARD11, CREBBP, KMT2A, KMT2D, MALT1, MYD88, NOTCH1, TET2
Heme Blood Mantle Cell Lymphoma (MCL) CCND1, CCND2, TP53
Heme Blood Burkitt Lymphoma (BL) ARID1A, BCL2, BCL6, ID3, MYC, SMARCA4, TP53
Heme Blood Waldenstrom Macroglobulinemia/Lymphoplasmocytic Lymphoma (WM) ARID1A, CXCR4, MYD88
Heme Blood Hairy Cell Leukemia (HCL) BRAF, CCND3, CDKN1B, KMT2C, MAP2K1, NF1, U2AF1
Heme Blood ADULT ALL (BLL,TLL) ABL1, ABL2, CRLF2, CSF1R, EPOR, ETV6, FLT3, IKZF1, IL3, IL7R, JAK1, JAK2, JAK3, KMT2A, PDGFRB, SH2B3, TCF3, RUNX1
Heme Blood PEDIATRIC ALL (BLL, TLL) ABL1, ABL2, CDKN2A, CRLF2, CSF1R, EPOR, FGFR1, FLT3, IKZF1, IL3, IL7R, JAK1, JAK2, JAK3, KMT2A, PDGFRB, RUNX1, SH2B3, TCF3