Advanced molecular profiling technologies

 

Sema4 Signal WES/WTS and Sema4 Signal PanCancer integrate tumor-normal matched WES with WTS to deliver the most comprehensive molecular insights:

• • • Hybrid capture-based next generation sequencing of 18,500 genes

 

• • • Run on the Illumina NovaSeq 6000 system in our CLIA-certified, CAP-accredited lab

 

• • • Reporting of:

• • • • SNVs, In/Dels
      • CNVs
      • Arm and whole chromosome aneuploidies
      • Gene fusions (RNA)
      • Spice variants (RNA)

 

• • • Assessment of:

• • • • TMB
      • MSI
      • PD-L1 antibodies 22C3 and SP142

 

• • • Tumor-normal sequencing to enable differentiation between somatic and germline alterations

 

• • • Target sequencing depth:

• • • • Tumor: 250X
      • Normal: 100X
      • RNA: 100M reads

 

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