Billing Resources


Accessing and paying for Sema4 tests is simple


Sema4 has contracts with all major national payors including but not limited to Aetna, Blue Cross Blue Shield, Cigna, Humana, and United Healthcare. We offer insurance analysis if you want to learn more about your benefits and estimated out of pocket costs to ensure there are no financial surprises.

If you have any questions about billing, payment options or financial assistance, please fill out the form below or call 1-800-298-6470 to contact our billing specialists.

Patient Payment

If you have an existing account, please visit the Sema4 Patient Portal to view and pay your bill.


Navigating your Sema4 Bill

Bills can be confusing, so we’re here to help. To deliver clarity, we have provided a detailed statement of charges for services rendered at Sema4. Learn more.


Explanation of Benefits (EOB) vs a Bill

When you receive an Explanation of Benefits (EOB) don’t confuse it with an actual bill. Learn more.


Billing FAQ’s

Sema4’s Billing Frequently Asked Questions are provided to keep you informed so that you know what to expect throughout each step of the process. View FAQs.


How can we help?

Kindly fill out the form below and we’ll schedule a time to discuss your needs.
You’re also welcome to call us at 1-800-298-6470.