Additional pharmacogenetic analysis for children


Every Sema4 Natalis order includes an additional pharmacogenetic analysis of a child’s response to more than 40 medications that may be prescribed during childhood. This analysis can help doctors personalize treatment for a child throughout their life.

Discover whether a child is likely to experience side effects or sensitivity to more than 40 medications*, including common antibiotics. For example, this analysis detects a genetic mutation known to cause sensitivity to a common antibiotic called gentamicin. Early detection of this mutation and avoidance of gentamicin may help prevent serious side effects, including hearing loss.

This test is included with every order of Sema4 Natalis, a genetic screen for 193 childhood genetic conditions.


  • Analgesics

  • Celecoxib (CYP2C9)
  • Codeine (CYP2D6)
  • Hydrocodone (CYP2D6)
  • Oxycodone (CYP2D6)
  • Tramadol (CYP2D6)
  • Antibiotics

  • Aminoglycosides (MT-RNR1)
  • Anticoagulants

  • Warfarin (CYP2C9, VKORC1)
  • Anticonvulsants

  • Fosphenytoin (CYP2C9)
  • Phenytoin (CYP2C9)
  • Antiemetics

  • Ondansetron (CYP2D6)
  • Antifungal Agents

  • Voriconazole (CYP2C19)
  • Antidepressants

  • Amitriptyline (CYP2D6, CYP2C19)
  • Citalopram (CYP2C19)
  • Clomipramine (CYP2D6, CYP2C19)
  • Desipramine (CYP2D6)
  • Doxepin (CYP2D6, CYP2C19)
  • Escitalopram (CYP2C19)
  • Fluoxetine (CYP2D6)
  • Fluvoxamine (CYP2D6)
  • Imipramine (CYP2D6)
  • Nortriptyline (CYP2D6)
  • Paroxetine (CYP2D6)
  • Sertraline (CYP2C19)
  • Trimipramine (CYP2D6, CYP2C19)
  • Antilipemic Agents

  • Simvastatin (SLCO1B1)
  • Antineoplastic Agents

  • Capecitabine (DPYD)
  • Fluorouracil (DPYD)
  • Mercaptopurine (TPMT)
  • Thioguanine (TPMT)
  • Antiplatelet Agents

  • Clopidogrel (CYP2C19)
  • Antipsychotics

  • Aripiprazole (CYP2D6)
  • Iloperidone (CYP2D6)
  • Pimozide (CYP2D6)
  • Antiretrovirals

  • Atazanavir (UGT1A1)
  • Immunosuppressants

  • Azathioprine (TPMT)
  • Tacrolimus (CYP3A5)
  • Enzyme Inhibitors

  • Eliglustat (CYP2D6)
  • Psychotropics

  • Atomoxetine (CYP2D6)
*Please note that almost all individuals will test positive for a variant in at least one of the 10 genes on this panel.