Actionable insights into solid tumor cancers

Sema4 Solid Tumor Panel analyzes 161 of the most relevant cancer driver genes to help doctors find the right treatment, the first time

 

The Sema4 Solid Tumor Panel uses next-generation sequencing (NGS) technology to test for actionable somatic mutations in solid tumors.


Highly accurate >99% sensitivity and specificity*
Comprehensive >99% of mutations associated with FDA-approved therapies, standard-of-care treatments, and investigational therapies in clinical trials
Actionable Delivers insights to guide targeted therapy or clinical trial selection
Advanced Powered by the Oncomine platform, a next-generation sequencing solution used by leading global research institutions and clinical trials, including the NCI-MATCH trial

*Compared against a series of cases with known or previously-tested mutations by other NGS methods.

Based on an analysis of actionable alterations from OncoKB. For additional information, please see Chakrevarty D, Gao K, Phillips S, et al. OncoKB: A Precision Oncology Knowledge Base. JCO Precision Oncology. 2017.

Powerful insights to help personalize treatment

 

This test is designed to help identify appropriate targeted therapies and clinical trials. The Solid Tumor Panel tests for clinically significant mutations in solid tumor cancers, including

 
   
20+ genes found in 15+ guidelines for solid tumor genetic testing 115+ genes included in 800+ clinical trials worldwide 15+ genes associated with 30+ targeted therapies that are approved by the FDA
 
Download a clinical overview to learn more about the Solid Tumor Panel

Analyzes 161 of the most relevant cancer driver genes

Genes interrogated by the Solid Tumor Panel

Hotspot regions sequenced 87 genes AKT1, AKT2, AKT3, ALK, AR, ARAF, AXL, BRAF, BTK, CBL, CCND1, CDK4, CDK6, CHEK2, CSF1R, CTNNB1, DDR2, EGFR, ERBB2, ERBB3, ERBB4, ERCC2, ESR1, EZH2, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, FOXL2, GATA2, GNA11, GNAQ, GNAS, H3F3A, HIST1H3B, HNF1A, HRAS, IDH1, IDH2, JAK1, JAK2, JAK3, KDR, KIT, KNSTRN, KRAS, MAGOH, MAP2K1, MAP2K2, MAP2K4, MAPK1, MAX, MDM4, MED12, MET, MTOR, MYC, MYCN, MYD88, NFE2L2, NRAS, NTRK1, NTRK2, NTRK3, PDGFRA, PDGFRB, PIK3CA, PIK3CB, PPP2R1A, PTPN11, RAC1, RAF1, RET, RHEB, RHOA, ROS1, SF3B1, SMAD4, SMO, SPOP, SRC, STAT3, TERT, TOP1, U2AF1, XPO1
All coding exons sequenced 48 genes ARID1A, ATM, ATR, ATRX, BAP1, BRCA1, BRCA2, CDK12, CDKN1B, CDKN2A, CDKN2B, CHEK1, CREBBP, FANCA, FANCD2, FANCI, FBXW7, MLH1, MRE11, MSH2, MSH6, NBN, NF1, NF2, NOTCH1, NOTCH2, NOTCH3, PALB2, PIK3R1, PMS2, POLE, PTCH1, PTEN, RAD50, RAD51, RAD51B, RAD51C, RAD51D, RB1, RNF43, SETD2, SLX4, SMARCA4, SMARCB1, STK11, TP53, TSC1, TSC2
Copy number variations queried 43 genes AKT1, AKT2, AKT3, ALK, AR, AXL, BRAF, CCND1, CCND2, CCND3, CCNE1, CDK2, CDK4, CDK6, EGFR, ERBB2, ESR1, FGF19, FGF3, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, IGF1R, KIT, KRAS, MDM2, MDM4, MET, MYC, MYCL, MYCN, NTRK1, NTRK2, NTRK3, PDGFRA, PDGFRB, PIK3CA, PIK3CB, PPARG, RICTOR, TERT
Rearrangements or fusions queried 51 genes AKT2, ALK, AR, AXL, BRAF, BRCA1, BRCA2, CDKN2A, EGFR, ERBB2, ERBB4, ERG, ESR1, ETV1, ETV4, ETV5, FGFR1, FGFR2, FGFR3, FGR, FLT3, JAK2, KRAS, MDM4, MET, MYB, MYBL1, NF1, NOTCH1, NOTCH4, NRG1, NTRK1, NTRK2, NTRK3, NUTM1, PDGFRA, PDGFRB, PIK3CA, PPARG, PRKACA, PRKACB, PTEN, RAD51B, RAF1, RB1, RELA, RET, ROS1, RSPO2, RSPO3, TERT

Testing includes microsatellite instability (MSI) analysis to identify patients who may be candidates for immunotherapy or MSI-indicated clinical trials

  • Designed for use in solid tumors
  • May help identify Lynch Syndrome in colon and endometrial cancers

Markers interrogated by the MSI analysis
Multiplexed markers
  BAT‑25, BAT‑26, MONO‑27, NR‑21, NR‑24