Common Cancer Management Panel

 
Test code: GDB751

Related gene(s): APC, ATM, AXIN2, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDKN2A, CHEK2, EPCAM, FH, FLCN, HOXB13, MLH1, MSH2, MSH6, MUTYH, NF1, NTHL1, PALB2, PMS2, POLD1, POLE, PTEN, RAD51C, RAD51D, SCG5 (GREM1), SDHB, SDHC, SDHD, SMAD4, STK11, TP53, TSC1, TSC2, VHL

Test description:

This panel is designed to maximize diagnostic yield for individuals with personal and/or family history of cancer and includes genes for the most frequent forms of hereditary cancer, including breast, colon, uterine, ovarian, and pancreatic cancers. Many of these genes have published management guidelines and clinically actionable interventions.

Conditions:

  • Colorectal Cancer
  • Familial Adenomatou Polyposis (FAP)
  • Pancreatic Cancer
  • Breast Cancer
  • Endometrial Cancer
  • Ovarian Cancer
  • Attenuated Familial Adenomatous Polyposis (AFAP)
  • Lynch syndrome

 
Clinical utility:

  • Cancer at a young age, such as breast, colon, or renal cancer
  • Multiple cancers in one person, either of the same origin (such as two separate colon cancers) or of different origins (such as breast cancer and ovarian cancer)
  • Diagnosis of certain rare cancers, such as ovarian or male breast cancer
  • Multiple relatives diagnosed with the same or related cancers on the same side of the family and spanning multiple generations

 
Lab method:

  • Deletion/duplication analysis
  • Next-Gen sequencing

Specimen Requirements

  • Preferred: 2-5 mL Blood – Lavender Top Tube
  • Alternative: Buccal Swabs, Fibroblasts (separate charge for cell culture may apply)

Ordering Information

  • CPT code(s):* 81432×1, 81433×1
  • Turnaround Time:** 2 weeks


*The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.
**Reporting times are typical and begin once the sample(s) are received at the GeneDx laboratory, but could be extended in situations outside GeneDx’s reasonable control.


Resources

Hereditary Cancer Requisition
Hereditary Cancer Re-requisition
GeneDx Test Information Sheet (TIS)