CYP2C19 Genotyping

Related Gene(s): CYP2C19

The human cytochrome P450 superfamily is responsible for metabolizing exogenous and endogenous substrates. The cytochrome P450-2C19 (CYP2C19) enzyme contributes to the metabolism of a large number of clinically relevant drug classes and drugs such as antidepressants, benzodiazepines, mephenytoin, proton pump inhibitors, and the antiplatelet prodrug, clopidogrel. The CYP2C19 gene is located within a cluster of cytochrome P450 genes (centromere-CYP2C18-CYP2C19-CYP2C9-CYP2C8-telomere) on chromosome 10q23.33. The CYP2C19 gene has nine exons and is highly polymorphic, with over 35 variant star (*) alleles currently defined by the Human Cytochrome P450 Allele Nomenclature Committee.

This targeted genotyping test interrogates the following variants: No function – *2, *3, *4, *5, *6, *7, *8; increased function – *17.

Specimen Requirements


  • Anticoagulated blood: Two 5-10 mL tubes with EDTA (lavender top) are preferred. ACD tubes (yellow top) are also accepted
  • Additionally, we can accept saliva specimens

Ordering Information


  • Ship at room temperature

Turnaround Time

  • 7-10 days


General Test Requisition