Billing Resources


Comprehensive offerings and convenient support
tailored to your patients needs


Accessing and paying for Sema4 tests is simple for both you and your patients with our robust in-network payer contracts, convenient billing and insurance reimbursement options. Please view the information below or visit our FAQ page here.

Insurance Billing

Sema4 is in network with a majority of regional and national health plans, including but not limited to Aetna, Blue Cross Blue Shield, Cigna, Humana, and United Healthcare. For a full list of in-network plans, visit our In-Network Contracts page.

For specific insurance inquiries, please fill out the form below or call 1-800-298-6470, to contact our team of billing specialists.


Insurance Analysis

We offer insurance analysis for your patients to learn more about their benefits to ensure there are no financial surprises. We work with providers to support the prior authorization process to help minimize unnecessary denials. Our appeals team will assist with the appeals process on behalf of the provider or patient, if designated.


Self-Pay & Financial Assistance

If insurance is not an option, patients can choose to pay directly. Our patient support team assists patients who need financial assistance or payment plans. If you or your patients have any questions about billing or payment options, please fill out the form below or call 1-800-298-6470.


Institutional Accounts

We will work with your practice to set up an account to receive monthly invoices for easy, transparent billing. For more information regarding institutional pricing please email or call 1-800-298-6470. Inquiries from Donor Facilities (based in the U.S. or in another country) can simply fill out the form below.


International Accounts

We work with clients around the world. For more information on inquires outside of the U.S., please email or call 1-800-298-6470.


How can we help?

Kindly fill out the form below and we’ll schedule a time to discuss your needs.
You’re also welcome to call us at 1-800-298-6470.